Acne Treatments
Struggling with Acne?
How we use regenerative medicine for aesthetics
Acne Vulgaris, a common skin condition affecting millions worldwide, is primarily caused by a combination of factors involving the hair follicles and oil-producing sebaceous glands. Hormonal fluctuations, particularly during adolescence, can lead to increased sebum production, a waxy, oily substance that normally helps keep the skin lubricated. However, excess sebum, along with dead skin cells, can clog hair follicles, creating an environment conducive to the growth of acne-causing bacteria, predominantly Propionibacterium acnes.
Inflammation is a key component of acne development. When follicles become blocked, the bacteria multiply, triggering an immune response that manifests as redness, swelling, and pus-filled lesions. Genetics also play a role in acne susceptibility, as individuals with a family history of the condition may be more prone to developing it.
Traditional acne treatments often focus on topical solutions, antibiotics, or hormonal therapies to manage symptoms. However, the emerging field of regenerative medicine offers promising avenues for addressing the root causes of acne. Stem cell therapy, a form of regenerative medicine, holds particular potential.
Stem Cell Infused Skin Therapy
Stem cells possess unique abilities to differentiate into various cell types, promoting tissue repair and regeneration. Researchers are exploring the use of stem cells to target the factors contributing to acne. One approach involves utilizing mesenchymal stem cells to modulate the immune response and reduce inflammation associated with acne lesions. These cells can also enhance tissue repair, potentially aiding in the healing of damaged skin.
Additionally, regenerative medicine explores the application of growth factors and cytokines to promote balanced sebum production and prevent the clogging of follicles. This innovative approach aims not only to alleviate existing acne symptoms but also to address the underlying causes, offering a more comprehensive and long-lasting solution.
While regenerative medicine for acne is still in the early stages of research and development, the potential to revolutionize acne treatment by targeting its fundamental mechanisms is a promising prospect for the future of dermatological care.
Amniotic fluid-derived mesenchymal stem cell products combined with microneedling for acne scars: A split-face clinical, histological, and histometric study
Abstract
Background: Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars.
Objective: To compare efficacy of amniotic fluid-derived mesenchymal stem cell-conditioned media (AF-MSC-CM) and microneedling vs microneedling alone in management of atrophic acne scars.
Methods: Ten cases with atrophic postacne scars received five sessions of microneedling, with 2-week interval on both sides of the face. Then, AF-MSC-CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions.
Results: There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF-MSC-CM) vs left side of face (dermaroller; P < 0.001). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, significant increase in epidermal thickness on both sides of face was detected.
Conclusion: Amniotic fluid-derived mesenchymal stem cell-conditioned media combined with microneedling is more effective in management of atrophic postacne scars than microneedling alone.